Glucarpidase

(gloo kar' pi dayz)

Brand Name(s): Voraxaze^®

WHY is this medicine prescribed?

Glucarpidase is used to prevent harmful effects of methotrexate (Rheumatrex, Trexall) in patients with kidney disease who are receiving methotrexate to treat certain types of cancer. Glucarpidase is in a class of medications called enzymes. It works by helping to break down and remove methotrexate from the body.

Are there OTHER USES for this medicine?

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

HOW should this medicine be used?

Glucarpidase comes as a powder to be mixed with liquid and injected intravenously (into a vein). It is usually given over 5 minutes as a one-time dose. Glucarpidase is given along with leucovorin (another medication used to prevent harmful effects of methotrexate) until laboratory tests show treatment is no longer needed.

What SPECIAL PRECAUTIONS should I follow?

Before taking glucarpidase,

• tell your doctor and pharmacist if you are allergic to glucarpidase, any other medications, or any of the ingredients in glucarpidase injection. Ask your pharmacist for a list of the ingredients.

• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: folic acid (Folicet, in multivitamins); levoleucovorin (Fusilev); or pemetrexed (Alimta). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

• if you are receiving leucovorin, it should be given at least 2 hours before or 2 hours after glucarpidase.

• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking glucarpidase, call your doctor.

What SPECIAL DIETARY instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What SIDE EFFECTS can this medicine cause?

Glucarpidase may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• nausea
• vomiting

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

• fever
• chills
• flushing or feeling hot
• rash
• hives
• itching
• throat tightness or difficulty breathing
• feelings of numbness, tingling, pricking, burning, or creeping on the skin
• headache

Glucarpidase may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What OTHER INFORMATION should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to glucarpidase.

Ask your pharmacist any questions you have about glucarpidase.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS^® Patient Medication Information™. © Copyright, 2024. The American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

Selected Revisions: February 15, 2013.