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Our Health Library information does not replace the advice of a doctor. Please be advised that this information is made available to assist our patients to learn more about their health. Our providers may not see and/or treat all topics found herein.

chlorpromazine (oral/injection)

Pronunciation: klor PROE ma zeen

Brand: Ormazine, Thorazine

ChlorproMAZINE Hydrochloride

slide 1 of 17, ChlorproMAZINE Hydrochloride,

25 mg, round, brown, imprinted with SZ 202

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ChlorproMAZINE Hydrochloride

slide 2 of 17, ChlorproMAZINE Hydrochloride,

50 mg, round, brown, imprinted with SZ 203

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ChlorproMAZINE Hydrochloride

slide 3 of 17, ChlorproMAZINE Hydrochloride,

100 mg, round, brown, imprinted with SZ 225

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ChlorproMAZINE Hydrochloride

slide 4 of 17, ChlorproMAZINE Hydrochloride,

10 mg, round, brown, imprinted with 832 10

Image of ChlorproMAZINE Hydrochloride
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ChlorproMAZINE Hydrochloride

slide 5 of 17, ChlorproMAZINE Hydrochloride,

25 mg, round, brown, imprinted with 832 25

Image of ChlorproMAZINE Hydrochloride
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ChlorproMAZINE Hydrochloride

slide 6 of 17, ChlorproMAZINE Hydrochloride,

50 mg, round, brown, imprinted with 832 50

Image of ChlorproMAZINE Hydrochloride
slide 6 of 17
    

ChlorproMAZINE Hydrochloride

slide 7 of 17, ChlorproMAZINE Hydrochloride,

100 mg, round, brown, imprinted with 832 100

Image of ChlorproMAZINE Hydrochloride
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ChlorproMAZINE Hydrochloride

slide 8 of 17, ChlorproMAZINE Hydrochloride,

200 mg, round, brown, imprinted with 832 200

Image of ChlorproMAZINE Hydrochloride
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ChlorproMAZINE Hydrochloride

slide 9 of 17, ChlorproMAZINE Hydrochloride,

10 mg, round, beige, imprinted with GG 455, 10

Image of ChlorproMAZINE Hydrochloride
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ChlorproMAZINE Hydrochloride

slide 10 of 17, ChlorproMAZINE Hydrochloride,

100 mg, round, brown, imprinted with GG 437, 100

Image of ChlorproMAZINE Hydrochloride
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ChlorproMAZINE Hydrochloride

slide 11 of 17, ChlorproMAZINE Hydrochloride,

100 mg, round, yellow, imprinted with 832 100

Image of ChlorproMAZINE Hydrochloride
slide 11 of 17
    

ChlorproMAZINE Hydrochloride

slide 12 of 17, ChlorproMAZINE Hydrochloride,

200 mg, round, brown, imprinted with GG 457, 200

Image of ChlorproMAZINE Hydrochloride
slide 12 of 17
    

ChlorproMAZINE Hydrochloride

slide 13 of 17, ChlorproMAZINE Hydrochloride,

200 mg, round, yellow, imprinted with 832 200

Image of ChlorproMAZINE Hydrochloride
slide 13 of 17
    

ChlorproMAZINE Hydrochloride

slide 14 of 17, ChlorproMAZINE Hydrochloride,

25 mg, round, yellow, imprinted with 25, GG 476

Image of ChlorproMAZINE Hydrochloride
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ChlorproMAZINE Hydrochloride

slide 15 of 17, ChlorproMAZINE Hydrochloride,

25 mg, round, yellow, imprinted with 832 25

Image of ChlorproMAZINE Hydrochloride
slide 15 of 17
    

ChlorproMAZINE Hydrochloride

slide 16 of 17, ChlorproMAZINE Hydrochloride,

50 mg, round, brown, imprinted with GG 407, 50

Image of ChlorproMAZINE Hydrochloride
slide 16 of 17
    

ChlorproMAZINE Hydrochloride

slide 17 of 17, ChlorproMAZINE Hydrochloride,

50 mg, round, yellow, imprinted with 832 50

Image of ChlorproMAZINE Hydrochloride
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What is the most important information I should know about chlorpromazine?

Call your doctor at once if you have uncontrollable movements of your eyes, lips, tongue, face, arms, or legs. These could be early signs of dangerous side effects.

Chlorpromazine is not approved for use in older adults with dementia-related conditions.

What is chlorpromazine?

Chlorpromazine is an anti-psychotic medication in a group of drugs called phenothiazines (FEEN-oh-THYE-a-zeens).

Chlorpromazine is used to treat psychotic disorders such as schizophrenia or manic-depression in adults.

Chlorpromazine is also used in adults to treat nausea and vomiting, anxiety before surgery, chronic hiccups, acute intermittent porphyria, and symptoms of tetanus.

In children ages 1 through 12 years, chlorpromazine is used to treat severe behavioral problems (such as combative or explosive behavior) or hyperactivity with excessive motor activity.

Chlorpromazine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using chlorpromazine?

You should not use this medicine if you are allergic to chlorpromazine or other phenothiazines (such as fluphenazine, perphenazine, prochlorperazine, promethazine, thioridazine, or trifluoperazine).

Do not use chlorpromazine if you have recently used large amounts of alcohol or medicine that makes you sleepy.

Chlorpromazine may increase the risk of death in older adults with dementia-related conditions and is not approved for this use.

Tell your doctor if you have ever had:

  • severe asthma, emphysema, or other breathing problem;
  • a sulfite allergy;
  • bone marrow suppression;
  • heart disease;
  • liver or kidney disease;
  • breast cancer;
  • glaucoma;
  • Parkinson's disease;
  • seizures;
  • a blockage in your intestines;
  • a brain tumor; or
  • pheochromocytoma (tumor of the adrenal gland).

Tell your doctor if you will be exposed to extreme heat, or to insecticide poisons while you are using chlorpromazine.

Do not give this medicine to a child without medical advice. Talk with your doctor before giving chlorpromazine to a child who has been ill with a fever or flu symptoms.

Using antipsychotic medicine in the last 3 months of pregnancy may cause medical problems, breathing problems, feeding problems, or withdrawal symptoms in the newborn. However, you may have withdrawal symptoms or other problems if you stop using your medicine during pregnancy. If you get pregnant, tell your doctor right away. Do not stop using chlorpromazine without your doctor's advice.

You should not breast-feed while using this medicine.

How should I use chlorpromazine?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Chlorpromazine oral is taken by mouth.

Chlorpromazine injection is injected into a muscle, or given as an infusion into a vein. A healthcare provider will give you this injection.

You may be asked to lie down for a short time after you receive a chlorpromazine injection. This medicine can lower your blood pressure and you may feel light-headed after an injection.

Your doctor will need to check your progress on a regular basis. Your vision may also need to be checked.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using chlorpromazine.

If you need to have a spinal tap (lumbar puncture) or any type of x-ray scan or MRI of your spinal cord, tell the doctor ahead of time that you are using chlorpromazine.

Do not stop using chlorpromazine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.

Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include dry mouth, bloating or stomach cramps, feeling restless, fever, muscle stiffness, jerky muscle movements, changes in heart rate, fainting, or seizure (convulsions).

What should I avoid while using chlorpromazine?

Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Drinking alcohol with this medicine can cause side effects.

Avoid exposure to sunlight or tanning beds. Chlorpromazine can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

What are the possible side effects of chlorpromazine?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Long-term use of chlorpromazine can cause a serious movement disorder that may not be reversible. The longer you use chlorpromazine, the more likely you are to develop this disorder, especially if you are a an older adult.

Call your doctor at once if you have:

  • uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);
  • stiffness in your neck, tightness in your throat, trouble breathing or swallowing;
  • a light-headed feeling, like you might pass out;
  • confusion, agitation, feeling jittery, trouble sleeping;
  • weakness;
  • breast swelling or discharge;
  • a seizure;
  • jaundice (yellowing of the skin or eyes);
  • low white blood cell counts --fever, chills, mouth sores, skin sores, sore throat, cough, trouble breathing, feeling light-headed; or
  • severe nervous system reaction --very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Some side effects may be more likely in older adults.

Common side effects may include:

  • drowsiness;
  • dry mouth or stuffy nose;
  • blurred vision;
  • constipation; or
  • impotence, trouble having an orgasm.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect chlorpromazine?

Using chlorpromazine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Other drugs may affect chlorpromazine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about chlorpromazine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2019 Cerner Multum, Inc. Version: 14.01. Revision date: 5/2/2019.

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